Interstitial Cystitis and CBD Oil
Interstitial Cystitis is a kind of chronic bladder condition that usually impacts women who are in their 30s and up. There have been numerous studies showing that cannabis can help to reduce bladder inflammation while managing urinary frequency and some pain symptoms.
Interstitial Cystitis Overview
Also known as painful bladder syndrome, interstitial cystitis is a condition that causes severe pressure on the bladder and pain that brings about the need to urinate on a frequent basis. This chronic condition happens to be more prominent in women than it is in men. The interstitial cystitis condition will cause a person to feel the need to have to urinate more often, even when the bladder is only holding a small volume of urine.
The pain that is associated with the interstitial cystitis condition is usually located in the pelvic region and along the area between the anus and vagina in women, or between the anus and scrotum in men. The symptoms that are associated with intensive interstitial cystitis will usually fluctuate, sometimes flaring up as a response to periods of sitting down for a long time, menstruation, sexual activity, exercise or stress. This is a condition that can lead to a stiffening in the bladder wall, which then reduces that capacity of the bladder, making it so that the person will have to urinate more often. This frequent urination and pain that is experienced will interfere with daily life.
The cause of this condition is unknown, but there is a defect that has been associated with interstitial cystitis, which can lead to toxic substances in the urine that will irritate the bladder wall. There is no cure for this condition; however, there are certain medications and therapies like bladder training, nerve stimulation and stretching of the bladder, that can help with managing the symptoms.
Interstitial Cystitis And The Effects Of Cannabis
Research has shown that cannabis can reduce inflammation in the bladder, along with urinary frequency, due to tot he impacts on the endocannabinoid system of the body. The cannabinoid receptors CB1 and CB2 Receptors are located in the human bladder. THC, tetrahydrocannabinol and cannabidiol, CBD, are two major cannabinoids that you will find in cannabis. They activate the CB2 receptors in the endocannabinoid system.
In one animal study, researchers were able to find that the activation of the CB2 receptors with the cannabinoids were effective when it comes to inhibiting inflammation. The swelling of the bladder was reduced, and the frequency of urination was inhibited in the group that had received cannabinoid treatment. The findings suggested that the CBD and THC, which activate these CB2 receptors, could help in the treatment of certain chronic bladder diseases like interstitial cystitis.
Another study went on to confirm that the activation of the CB2 receptors with the cannabinoid inhibited the bladder inflammation severity. In the animal studies, the THC and other cannabinoids were found to cut back on the electrically evoked bladder contractions, suggesting a relationship between bladder function and the CB1 receptors.
With administration of CBD and THC, there was a decrease in urinary urgency as well as the volume and number of incontinence episodes in patients with multiple sclerosis and bladder dysfunction. Additionally, pain and the quality of sleep was noted as increasing significantly. Other studies found how cannabis was able to reduce the different urge incontinence episodes in patients who have multiple sclerosis.
Marijuana has been shown to be effective when it comes to managing the pain that is linked to interstitial cystitis. In one case study, the findings proved that a 31-year-old woman who had been diagnosed with the condition of chronic cystitis, and that also had pain that was intractable to the other treatments for about 20 years, had experienced a major reduction in the pain she was experiencing while taking the oral THC. Throughout the treatment process, the patient had to cut back on the dosage because of the various psychotic side effects, the confusion and some of the bad dreams she had been having. However, after the dosage had been cut back to a safer level, the patient was able to continue with the reduction in pain along with less of the side effects. She remained stable for about six months until the time that the case study was able to be completed.
An animal study went to show that THC can be active when it comes to suppressing the pain in some hypersensitive bladder disorders like interstitial cystitis.
States That Approve Medical Marijuana For Treating Interstitial Cystitis
As of right now, only the state of Illinois supports medical marijuana for the treatment of the interstitial cystitis condition. In Washington D.C., any condition could be passed for the use of medical marijuana just as long as an area licensed physician recommends such treatment. Additionally, some states will consider allowing medicinal marijuana to be used for interstitial cystitis treatment with a recommendation from a licensed physician.
Several states have approved medical marijuana for treating “chronic pain,” which is a common symptom associated with interstitial cystitis. These states include: Alaska, Arizona, California, Colorado, Delaware, Hawaii, Maine, Maryland, Michigan, Montana, New Mexico, Ohio, Oregon, Pennsylvania, Rhode Island and Vermont. The states of Nevada, New Hampshire, North Dakota, Montana, Ohio and Vermont allow medical marijuana to treat “severe pain.” The states of Arkansas, Minnesota, Ohio, Pennsylvania and Washington have approved cannabis for the treatment of “intractable pain.”
Recent Studies on Cannabis’ Effect on Interstitial Cystitis
- Activating the CB2 receptors with cannabinoids reduced bladder inflammation and urinary frequency in mice.
Treatment with a cannabinoid receptor 2 agonist decreases severity of established cystitis. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163202/)
- Regular THC and CBD treatments reduced pain that had proven intractable to other treatments in a 31-year old chronic cystitis patient.
A case of cannabinoid rotation in a young woman with chronic cystitis.