Isolated Humulene Terpene
- *Food-grade, natural, organic and non-GMO
- *Add to concentrates, edibles, topicals, etc.
- *Product development and formulations
- *Strain terpene profiles or proprietary blends
- *Maximize the “entourage effect”
- *Add to Tinctures of any brand
Humulene is good for:
*This product is SUPER HIGHLY CONCENTRATED- Precautions should be made and SDS Sheet read before usage.
Humulene emits a slightly bitter, woody aroma that is often reminiscent of hops. Strains known for their content of Humulene include Thin Mint, Chemdawg 91, and Sherbert. Isolated Humulene can be naturally sourced from hops (Humulus lupulus), sage (Salvia officinalis), japanese spicebush (Lindera obtusiloba), ginseng, spearmint (Mentha spicata), ginger (Zingiber officinale), and the Chinese laurel (Antidesma bunius). Humulene has been used as a topical to relieve inflammation and pain. Studies have indicated that the anti-inflammatory effect of Humulene may be comparable to that of some steroid alternatives. It has been widely acknowledged that Humulene works in similar fashion to cannabinoid THCV in the suppression of appetite.
Hops, Common Sage, Japanese Spicebush, Ginseng, Spearmint, Ginger, Chinese Laurel Tree
Anti-bacterial, Anti-cancer, Anti-inflammatory, Insecticide
The antibacterial activity of basal fir oil (Abies balsamea) seen to be effective with Staphylococcus aureus. At 2.6 microg/mL, humulene was shown to have a minimum inhibitory concentration, the most potent of all the terpenes evaluated in the study.
Pichette A. Composition and antibacterial activity of Abies balsamea essential oil.
Phytother Res. 2006 May;20(5):371-3.
Humulene was shown to be a good anti-inflammatory across a wide range of inflammatory markers. Its effects were comparable to dexamethasone in rat and mouse models. Humulene has been shown to have rapid onset and relatively good absorption with both oral and topical administration routes. In airway allergic inflammatory routes, humulene was shown to be effective orally or through aerosol.
Chaves JS. Pharmacokinetics and tissue distribution of the sesquiterpene alpha-humulene in mice. Planta Med. 2008 Nov;74(14):1678-83.
Fernandes ES. Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea.
Eur J Pharmacol. 2007 Aug 27;569(3):228-36. Epub 2007 May 22.
Alexandre P Rogerio. Preventive and therapeutic anti-inflammatory properties of the sesquiterpene α-humulene in experimental airways allergic inflammation.
Br J Pharmacol. 2009 Oct; 158(4): 1074–1087.
Humulene was elucidated to be potent against several solid tumor cell lines. The molecular mechanism involves producing reactive oxygen species, or free radicals, and depleting natural antioxidants in the cells. Humulene was also shown to work synergistically with beta-caryophyllene in delivering the molecule to cancer cells, thus increasing the cytotoxicity of humulene on several cancer cell lines.
Legault J. Antitumor activity of balsam fir oil: production of reactive oxygen species induced by alpha-humulene as possible mechanism of action.
Planta Med. 2003 May;69(5):402-7.
Legault J. Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel.
J Pharm Pharmacol. 2007 Dec;59(12):1643-7.
Tundis R. In vitro cytotoxic effects of Senecio stabianus Lacaita (Asteraceae) on human cancer cell lines.
Nat Prod Res. 2009;23(18):1707-18.
Humulene was shown to be toxic against early third-stage larvae of the malaria, dengue, and filariasis mosquito vectors, An. stephensi, Ae. aegypti, and Cx. Quinquefasciatus. Also humulene was proven to be a repellant to the adult mosquitos as well. In addition humulene was only toxic to non-pathogenic aquatic organisms, Diplonychus indicus and Gambusia affinis at much higher levels than those used against the mosquitos.
Govindarajan M. Larvicidal and repellent potential of Zingiber nimmonii (J. Graham) Dalzell (Zingiberaceae) essential oil: an eco-friendly tool against malaria, dengue, and lymphatic filariasis mosquito vectors?
Parasitol Res. 2016 Jan 21.
Synergistic effects with…
Anti-fungal – CBC, CBG
Anti-coagulant – THC
Insecticidal – THCA, CBGA
Beta-caryophyllene helps with cancer drug delivery when using humulene