CofABrochureShop
  • PO BOX 667988
    Miami, Florida 33166 USA
  • Phone
    1-855-380-3332
  • Wholesale
    1 855-380-3332

What is tetrahydrocannabinol (THC)

tetrahydrocannabinol (THC) 

“THC” redirects here. For other uses, see THC (disambiguation).
Tetrahydrocannabinol (THC)
INN: dronabinol
Tetrahydrocannabinol.svg
Delta-9-tetrahydrocannabinol-from-tosylate-xtal-3D-balls.png
Systematic (IUPAC) name
(−)-(6aR,10aR)-6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol
Clinical data
Trade names Marinol
License data
Pregnancy
category
  • US: C (Risk not ruled out)
Dependence
liability
8–10% (Relatively low risk of tolerance)[1]
Addiction
liability
Low
Routes of
administration
Orally, local/topical, transdermal, sublingual, inhaled
Legal status
Legal status
Pharmacokinetic data
Bioavailability 10–35% (inhalation), 6–20% (oral)[3]
Protein binding 97–99%[3][4][5]
Metabolism Mostly hepatic by CYP2C[3]
Biological half-life 1.6–59 h,[3] 25–36 h (orally administered dronabinol)
Excretion 65–80% (feces), 20–35% (urine) as acid metabolites[3]
Identifiers
CAS Number 1972-08-3 Yes
ATC code A04AD10 (WHO)
PubChem CID 16078
IUPHAR/BPS 2424
DrugBank DB00470 Yes
ChemSpider 15266 Yes
UNII 7J8897W37S Yes
ChEBI CHEBI:66964 
ChEMBL CHEMBL465 Yes
Synonyms  (6aR,10aR)-delta-9-tetrahydrocannabinol
Chemical data
Formula C21H30O2
Molar mass 314.469 g/mol
Specific rotation −152° (ethanol)
Physical data
Boiling point 157 °C (315 °F) [7]
Solubility in water 0.0028,[6] (23 °C) mg/mL (20 °C)
 Yes (what is this?)  (verify)

Tetrahydrocannabinol (THC, dronabinol by INN), or more precisely its main isomer (−)-trans9-tetrahydrocannabinol, is the principal psychoactive constituent (or cannabinoid) of cannabis. It can be an amber or gold colored glassy solid when cold, which becomes viscous and sticky if warmed.

Like most pharmacologically-active secondary metabolites of plants, THC in Cannabis is assumed to be involved in self-defense, perhaps against herbivores.[8] THC also possesses high UV-B (280–315 nm) absorption properties, which, it has been speculated, could protect the plant from harmful UV radiation exposure.[9][10][11]

THC, along with its double bond isomers and their stereoisomers, is one of only three cannabinoids scheduled by the UN Convention on Psychotropic Substances (the other two are dimethylheptylpyran and parahexyl). It was listed under Schedule I in 1971, but reclassified to Schedule II in 1991 following a recommendation from the WHO. Based on subsequent studies, the WHO has recommended the reclassification to the less-stringent Schedule III.[12] Cannabis as a plant is scheduled by the Single Convention on Narcotic Drugs (Schedule I and IV).

A pharmaceutical formulation is available by prescription in the U.S. and Canada under the brand name Marinol.

 

CBD Oil 1oz 500mg 20mg Per Serving
Amy from Reno
Total order for 125.98 USD
about 12 mins ago
 
Mary L from Lakeland
Total order for 29.63 USD
about 6 hours ago
 
cbd pure isolate
Jordan from Fleetwood
Total order for 237.50 USD
about 7 hours ago
 
CBD Pain Cream With 10% Emu Oil
Dominic from Pembroke Pines
Total order for 145.22 USD
about 8 hours ago
 
Elijah from Melbourne
Total order for 125.98 USD
about 8 hours ago
 
Michael from Butler
Total order for 64.99 USD
about 12 hours ago
 
CBD Oil Spray Sleep Support
Jeffrey from Thonotosassa
Total order for 52.98 USD
about 17 hours ago
 
Jim from Craig
Total order for 145.98 USD
about 1 day ago